NFL Week 2 Betting Guide: Matchups, Spreads and Odds for SI Sportsbook Perfect 10

Week 2 of the SI Sportsbook “Perfect 10” contest finds an intriguing card with seven of the 10 home teams listed as favorites. Simply backing the home team was slightly better than a coin flip for bettors in Week 1 as home teams went 9-7 (56%) against the spread (ATS).

Bettors find seven games for this week’s contest listed with point spreads of five points or less. Only two games on the card (Dolphins–Ravens; Buccaneers–Saints) Orleans) feature undefeated teams clashing. The three biggest favorites—49ers (-8.5), Broncos (-10.5) and Rams (-9.5)—are all playing at home.

Let’s take a quick look at the contest lines!

Bettors this season can take part in a free “Perfect 10” contest this season at SI Sportsbook. The weekly game requires bettors to make 10 selections against the spread for a chance at a share of a $10,000 prize. Every bettor who picks at least six games correctly will be awarded consolation prizes in the form of free bets.

Participate in the Perfect 10 contest at SI Sportsbook!

Dolphins (1-0; 1-0 ATS) vs. Ravens (1-0; 1-0 ATS)

PERFECT 10 CONTEST LINE: MIA +3.5 | BAL -3.5

PERFECT 10 Breakdown: After earning a solid win over the Patriots, Miami will put its recent 5-2-1 ATS road underdog record on the line heading into Baltimore. The Ravens, who are one of the best teams in the opening month under John Harbaugh, are 7-3 ATS in Week 2 over the last 10 seasons.

Colts (0-0-1; 0-1 ATS vs. Jaguars (0-1; 0-1 ATS)

PERFECT 10 CONTEST LINE: IND -4.5 | JAX +4.5

PERFECT 10 Breakdown: The Colts, coming off a disappointing 20-20 tie against the Texans as seven-point road favorites, will face another AFC South opponent. Respected money in Vegas could likely grab the points with a Jaguars squad that is 7-0 ATS (100%) in their last seven home meetings with Indianapolis. However, something will have to give in Week 2 as Jacksonville is a paltry 1-8 ATS (11%) in its last nine games dating back to last season.

Commanders (1-0; 1-0 ATS) vs. Lions (0-1; 1-0 ATS)

PERFECT 10 CONTEST LINE: WSH +2.5 | DET -2.5

PERFECT 10 Breakdown: Carson Wentz, after earning a win in his first game as a Commander, helped continue a solid trend as Washington is now 7-2-1 ATS (78%) in its last 10 games dating back to 2021. Jared Goff and the Lions, despite losing 38-35 to the Eagles, still extended their 5-0 ATS mark over their last five home games.

Christopher Hanewinckel-USA TODAY Sports

Panthers (0-1; 0-1 ATS) vs. Giants (1-0; 1-0 ATS)

PERFECT 10 CONTEST LINE: CAR +2.5 | NYG -2.5

PERFECT 10 Breakdown: The Giants, who showed moxie going for a two-point conversion to pull out a one-point road win at the Titans, are in a position they have recently struggled in. New York, who is a 2.5-point favorite, is 6-9 ATS (40%) in their last 15 games as a home favorite. The Panthers, on the flip side, are 3-13 ATS (19%) in their last 16 games after losing to the Browns at home in Week 1.

Patriots (0-1; 0-1 ATS) vs. Steelers (1-0; 1-0 ATS)

PERFECT 10 CONTEST LINE: NE -1.5 | PIT +1.5

PERFECT 10 Breakdown: After losing 20-7 at Miami, Mac Jones and the Patriots will play their second consecutive game away from Gillette Stadium in Week 2. Bill Belichick’s squad is a dismal 1-5 ATS dating back to last season. The under, which is 5-1 in the last six meetings between these AFC foes, has drawn respected action in Vegas, dropping the opening total of 43 down to 40.5. The Steelers were delivered a major blow in Week 1 when star defensive end T.J. Watt suffered a torn pectoral and is out indefinitely.

Buccaneers (1-0; 1-0 ATS) vs. Saints (1-0; 0-1 ATS)

Moneyline: Tampa Bay (-163) | New Orleans (+138)
Spread: TB -3 (-110) | NO +3 (-110)
Total: 44.5 – Over (-110) | Under (-110)
Game Info: Sept. 18, 2022 1 pm ET | FOX

PERFECT 10 CONTEST LINE: TB -2.5 | NO +2.5

PERFECT 10 Breakdown: The Saints have dominated the Buccaneers of late, winning seven of the last eight meetings with a corresponding 7-1 ATS mark. After easily beating the Cowboys, 19-3, on Sunday Night Football, Tampa Bay, which boasts a 8-3 ATS (73%) mark over its last 11 games, will play its second straight game on the road. Tom Brady will be missing one of his best weapons as wideout Chris Godwin (hamstring) is expected to miss multiple weeks.

Seahawks (1-0; 1-0 ATS) vs. 49ers (0-1; 0-1 ATS)

PERFECT 10 CONTEST LINE: SEA +8.5 | SF -8.5

PERFECT 10 Breakdown: The Seahawks, who are 7-3 ATS in their last 10 meetings in San Francisco, will head into battle following their big upset win over the Broncos. The 49ers, who are 10-3 ATS (including playoffs) over their 13 games, will look to rebound from their upset loss at the Bears. San Francisco backers will hope a return to Levi’s Stadium will be just the club needs as the 49ers are 4-0 ATS in the last four regular-season games in front of their home fans.

Gary A. Vasquez-USA TODAY Sports

Falcons (0-1; 1-0 ATS) vs. Rams (0-1; 0-1 ATS)

PERFECT 10 CONTEST LINE: ATL 9.5 | LAR -9.5

PERFECT 10 Breakdown: After dropping the season opener to the Bills, the defending Super Bowl champions welcome the Falcons to SoFi Stadium in Week 2. The Rams, who are 1-4 ATS in their last five games as the betting favorite, are a dismal 2-5 ATS (29%) over their last seven games despite winning it all last season. The Falcons, who covered as six-point underdogs in their loss versus New Orleans, are now 3-7 SU with an accompanying 3-6-1 ATS mark over their last 10 games.

Texans (0-0-1; 1-0 ATS) vs. Broncos (0-1; 0-1 ATS)

PERFECT 10 CONTEST LINE: HOU +10.5 | DEN -10.5

PERFECT 10 Breakdown: The Texans, who tied the Colts as seven-point underdogs, are 4-1 ATS in their last five games. However, Houston has been a solid fade as road underdogs, owning a 2-5 ATS record in their last seven games in that role. The Broncos, who are 5-10 ATS (33%) in their last 15 games, will now be asked to cover a double-digit spread after being upset in Russell Wilson‘s first start. After Monday’s poor showing, this spread is likely to be listed at single digits by kickoff.

Cardinals (0-1; 0-1 ATS) vs. Raiders (0-1; 0-1 ATS)

PERFECT 10 CONTEST LINE: ARZ +4.5 | LVR -4.5

PERFECT 10 Breakdown: The Cardinals, who were blown out 44-21 by the Chiefs, are 1-6 ATS in their last seven games. Kyler Murray will try to rebound against a Raiders club that has burned bettors when asked to lay points at Allegiant Stadium, sporting a 0-3 ATS mark in the last three as a home favorite. Following the dismal showing against the Chiefs, early respected steam has faded the Cardinals and pushed the opening spread of three points up to 5.5 points.

Frankie Taddeo is a successful high-stakes fantasy football player who created the first-ever DFS program ever offered in a Las Vegas sportsbook. Frankie is SI Betting’s Senior Analyst and provides his significant experience and resources in the sports betting scene. You can follow Frankie on Twitter @Frankie_Fantasy for his latest betting and fantasy insights from Las Vegas.

Get fantasy and betting analysis in your inbox by signing up for the Winners Club newsletter

Check the Latest Odds from SI Sportsbook

More Betting, Fantasy and NFL:
• Week 1 Betting Recap
• Bengals Large Week 2 Favorites
• AL MVP, Cy Young, Rookie of the Year Odds
• NL MVP, Cy Young, Rookie of the Year Odds
• Week 1 Fantasy Storylines
• NFL Power Rankings